SwampNut Posted May 11 Share Posted May 11 I know many of you will be more interested in the latter, but I'm more interested in how life-changing this has been for me, and for many others. The fact that they are "gouging" has to be measured against the immense effort to create it, and how much value it provides to society. What is it? Tirzepatide, brand name Mounjaro. It's a GLP-1 and GIP agonist, the first of its kind ever, with stunning results. What does this mean? It stabilizes blood sugar for type 2 diabetics, or like me, pre-diabetics. I don't have diabetes, but I also don't have fully normal/stable blood sugar. It's been an ongoing challenge. I also didn't know how much this factored into many other parts of health and life. It does it through multiple mechanisms; better insulin response, and slowed gastric emptying. If your food moves slower, you absorb it slower, and eat less of it. Mounjaro has a retail price of $1044 per month. Notice I said per month, not for any given quantity. This is the game I'm beating. It's sold in a pen injector, which delivers the entire thing in a quick subcutaneous shot. The pens come in milligram doses of 2.5, 5, 7.5, 10, and 15. Each is in a 0.5ml suspension. The price is the same. That's right, you pay the same to be "fixed" no matter the dosage. It is recommended to start at 2.5 weekly, and move up to 5 in four weeks. Then see how the results are and probably, but not always, continue moving up. I did none of that. After many many hours of research, I decided on a new course. Also, I had not realized that the pens were all the same price, and had no idea I could defeat them. See, I was prescribed the 2.5 dose, and even with a coupon and insurance, my price would be $750 per month. Motherfucker. My searching and reading led me to various sources of a generic version of the drug, which is not legal of course, so that also made me happy. Beating two systems at once? Cool. I started buying a dry powder version and reconstituting it myself, and just self injecting with a normal insulin needle. I paid $150 for 5mg at first, to see how it worked. That would still be expensive. The results were pretty much a miracle, I'll get to that later. Once I new I wanted more, I shopped harder and found a few other sources. One was $100 per 10mg vial, from a US vendor. They delivered in a few days. The other is in China, $490 for ten vials of 10mg, but delivery is a month-ish. Some people get it faster, some slower. So anyway, I've been using various vendors of the dry powder. Meanwhile, I learn about the game of the pens all being the same price. So it would be $750 for the four pens of 2.5, or for the four pens of 15. LOL, ok, I can see how to beat this. Inject the pen into a sterile vial, instead of my skin, and dispense from there. Too easy. Also feeds my love of hacking systems. Along with this, my reading led to the knowledge that the half-life of the drug is only 117 hours, so just under five days. The once a week recommendation from the manufacturer? Marketing, and ease of use for morons. It would be too hard to get patient compliance for dosing every 3, 4, or 5 days. And marketing "only once a week!" has a lot more power. Motherfuckers. So, I started on the dry powder at a rate of 2.5mg per three days. This is way more than a recommended starting dose. "Carlos, you moron, you're playing with your life and you think you know better than the doctors?" Nah, my doc said it's perfectly fine, but that I will feel shitty. The low recommendation is based on--marketing and patience acceptance. If you get hit with major side effects you may hate it and/or stop. So they start you on light side effect, but for longer. Fuck that bullshit. Rip the band-aid off. Give me all the problems hard, now, and get it over with. Also, I don't want the ups and downs of a weekly dose. I got a spreadsheet showing the blood accumulation levels, and ran calculations on what would get me to a therapeutic dose the fastest, and be maintainable. Again, doc says, you're not gonna die, roll with it. Actually he said "I can't advise you to ignore the recommendations, but you'll be fine." So my blood sugar is super stable. I went from hitting 160-some regularly and peaks of 190+ to never hitting 130 at all (which is the normal max). I went from a waking level of 105 (pre-diabetic level) to being in the 70s and 80s. They consider 100 to be pre-diabetic, and below 90 to be ideal. So cool, how does this change your life? Well, I'm suddenly sleeping all night. I'm suddenly full of energy most days, and have few energy drops that I had lived with and considered normal. And then, one day...a friend makes a comment that makes me realize that the tinnitus I was left with after COVID, is gone. And along with it the recurrent inner ear imbalance shit. This drug is implicated in a shitload of inflammatory issues and auto-immune issues being resolved. It's a possible treatment for MS and related disorders. Diabetes is an autoimmune disorder too (for those who are very aware of T1/T2 differences, new research says T2 probably is too). Blood sugar problems have a shitload of other effects, and they are all gone. The overall impact of the totality of the problem was hidden from me until they were gone. I'm not exaggerating when I say that it's massively life changing, in so many completely unpredictable ways, fixing things I've taken for granted for decades. I had this conversation with the guys at MotoGP; one of their wives has been taking it, and they say "life changing" is an under-exaggeration. Also MotoGP pointed out all my resolved issues. I got up way early, drove an hour, walked 8.1 miles through the entire day, drove an hour, sat around bullshitting, and was the last one ready for bed, at 2am. Got up at 7, drove an hour, only walked six miles this time, drove a couple hours for various reasons, and again last one to be tired. A side problem of diabetes is frequent urination, and being thirsty all the time, even while drinking lots of water. That would suck at the track, and driving a lot. But those things are gone. Done. A side effect of slowed gastric emptying is eating less. Being forced to eat less. Had to learn this. But great, eating more rationally is good. I learned I had extremely fast emptying, which led to never feeling full. The brain connection was fucked. It also means drinking less, including alcohol, and it has a very reduced effect. Wouldn't you want to drink more? Nope, the opposite. And then I find myself thinking, why are all my friends fucking drunk? Anyway, there's the long story. I still have more powder, and now I have my pens. I want to experiment with the real thing to build a baseline of expectations. I'm 90% sure one of the vendors is fucking me on overall potency/amount. But the way to know is to do the pens for a while, and then the dry, and compare results. I'm wearing a constant glucose monitor so every minute is tracked. And that was another pharma game to play, but this is already long enough. 1 Quote Link to comment Share on other sites More sharing options...
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