Is metformin a strong anti-aging pill even for non-diabetics?

[SwampNut]

The evidence seems extremely strong, with few side effects and extremely low cost.

Read the blurb, it’s something many doctors are starting to say about metformin.

 

Or watch this….

 

 

 

 

https://nutritionfacts.org/webinar/should-everyone-consider-taking-the-anti-aging-drugs-metformin-and-rapamycin/?mc_cid=2bd362f417

 

 

 

---------- Forwarded message ---------
From: Dr. Greger <no-reply@nutritionfacts.org>
Date: Jun 5, 2024 at 6:03:09 AM
Subject: Upcoming Webinar: Should Everyone Consider Taking the Anti-Aging Drugs Metformin and Rapamycin?

 

 

https://nutritionfacts.org/webinar/should-everyone-consider-taking-the-anti-aging-drugs-metformin-and-rapamycin/?mc_cid=2bd362f417

 

 
Dear Carlos,
Metformin is a drug that boosts the anti-aging enzyme AMPK, and rapamycin is a drug that suppresses the pro-aging enzyme mTOR. Metformin is so powerful that, compared to individuals without diabetes, people with diabetes who take metformin live longer. Rapamycin is considered a universal anti-aging drug, extending lifespan in every animal tested. Both drugs are off-patent, inexpensive, and widely available. Do the potential upsides outweigh the risks? Find out in this live 90-minute webinar on Friday, June 14, starting at 2pm ET.

Everyone registered for the webinar will receive the webinar recording within a few days of the presentation taking place. 

The Rochester Academy of Medicine designates this live activity for a maximum of 1.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Webinar Date & Time: Fri, June 14 at 2pm EDT
Last Day to Register: Wed, June 12
REGISTER FOR THE WEBINAR
 

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of The Rochester Academy of Medicine and NutritionFacts.org. The Rochester Academy of Medicine is accredited by the ACCME to provide continuing medical education for physicians.

None of the planners for this educational activity have relevant financial relationship(s) to disclose with ineligible companies whose primary business is producing, re-selling, or distributing healthcare products used by or on patients.
 

The videos I’ll present in the webinar will eventually be available for free on NutritionFacts.org, but if you don’t want to wait to get answers to your burning questions, join me for this live presentation and Q&A session.

Your support helps keep NutritionFacts.org going and growing! Thank you!

Yours in evidence-based nutrition,

Michael Greger, M.D., FACLM
NutritionFacts.org
 

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[jon haney]

Great.  I'll tell my wife that she will now live even longer after I have turned to dust.

[blackhawkxx]

So if you take this to live longer and smoke, drink and eat whatever you want, will it then balance it all out to a normal life span?   😉

[SwampNut]

Yeah, exactly how my theory on salty pork rinds works.  We all know that salt raises your BP and can give you a stroke.  And that greasy meats harden your arteries and block them.  The hardening stops stroke, the high BP prevents the blockage, so all good.

[SwampNut]

More evidence for it.  I decided, fuck it.  Costs nearly nothing, I can just get some, why not?  I'm doing the minimal dose, blood sugar is better, and I'm cutting back on tirzepatide.  That has lots of side effects and Metformin, for me, has zero sides.

 

https://nutritionfacts.org/video/does-metformin-work-as-a-life-extension-drug/?subscriber=true&utm_source=NutritionFacts.org&utm_campaign=e082c86ae9-EMAIL_CAMPAIGN_7_26_2022_12_48_COPY_01&utm_medium=email&utm_term=0_40f9e497d1-e082c86ae9-28710906&mc_cid=e082c86ae9

 

[blackhawkxx]

3 hours ago, SwampNut said:

More evidence for it.  I decided, fuck it.  Costs nearly nothing, I can just get some, why not?  I'm doing the minimal dose, blood sugar is better, and I'm cutting back on tirzepatide.  That has lots of side effects and Metformin, for me, has zero sides.

 

https://nutritionfacts.org/video/does-metformin-work-as-a-life-extension-drug/?subscriber=true&utm_source=NutritionFacts.org&utm_campaign=e082c86ae9-EMAIL_CAMPAIGN_7_26_2022_12_48_COPY_01&utm_medium=email&utm_term=0_40f9e497d1-e082c86ae9-28710906&mc_cid=e082c86ae9

 

I didn't watch the video but did you read the comments under it?  Here's a couple.

 

Metformin questionable to say the least leading to risk of b12 deficiency of particular concern to vegans.Berberine offered as an alternative though not for prengnancy.

 

I was diagnosed with Type 2 diabetes in 2006 and placed on metformin. It did a good job of managing my sugars but devastated my kidneys. My GRE was 17 ( you go on dialysis at 15) and they took me off metformin. My kidneys recovered, thanks in large part to a WFPB diet, but my diabetes is another story. Nothing else worked, I was briefly on insulin, but am now doing ok on Mounjaro. Heaven only knows what damage it is doing to my body, but my latest A1c was 5.9 and I can live with that (I hope)!

[superhawk996]

20 hours ago, SwampNut said:

More evidence for it.  I decided, fuck it.

I coulda sworn that you recently said Metformin is terrible....?

[SwampNut]

3 hours ago, superhawk996 said:

I coulda sworn that you recently said Metformin is terrible....?

 

I can't imagine why.  Maybe something different?  Maybe I mentioned that my friend who's on a high dose is having on super annoying side effect (but he'd be fucked without it)?  Would this have been an in person conversation?  "Metformin" doesn't appear here or in any of my data other than quoting studies and saying that it might help me.  I don't have an opinion on it really, outside of the medical studies seeming to be overwhelmingly favorable.  

 

The long term side effects of tirzepatide suck, and are dose dependent.  I need to try to back up from that, this is a potential tool.  June 15th I mentioned that I needed to do this and would try metformin, in the Zepbound thread.

[SwampNut]

And now, how it will kill you...

 

https://nutritionfacts.org/video/side-effects-of-metformin-as-a-life-extension-drug/?subscriber=true&utm_source=NutritionFacts.org&utm_campaign=dc92c42605-EMAIL_CAMPAIGN_7_26_2022_12_48_COPY_01&utm_medium=email&utm_term=0_40f9e497d1-dc92c42605-28710906&mc_cid=dc92c42605

 

 

Side Effects of Metformin as a Life-Extension Drug
Michael Greger M.D. FACLM · July 24, 2024 · Volume 66

5/5 - (5 votes) 
As a mild mitochondrial poison, metformin carries a variety of downsides.
 

[superhawk996]

On 7/23/2024 at 8:20 AM, SwampNut said:

I can't imagine why.  Maybe something different?  Maybe I mentioned that my friend who's on a high dose is having on super annoying side effect (but he'd be fucked without it)?  Would this have been an in person conversation?  "Metformin" doesn't appear here or in any of my data other than quoting studies and saying that it might help me.

It was the speaker phone call with Micheal and Jorge, I think it was a relative of Jorge that has diabetes and we were talking about different meds.  It was Thirsty Thursday and they stayed late so most of my memory was erased.

[SwampNut]

Hah, right, memory eraser by Sailor Jerry.  By the time we had that call, I was dabbling with it, so I can't imagine I would have been wholesale negative, but certainly could have expressed cautions.  If it was on my business line, I'd have a recording.

[SwampNut]

https://nutritionfacts.org/video/the-tame-trial-targeting-aging-with-metformin/?subscriber=true&utm_source=NutritionFacts.org&utm_campaign=7587e1145b-EMAIL_CAMPAIGN_7_26_2022_12_48_COPY_01&utm_medium=email&utm_term=0_40f9e497d1-7587e1145b-28710906&mc_cid=7587e1145b

 

 

The TAME Trial: Targeting Aging with Metformin

If you have diabetes, metformin can make things better, but if you don’t, the drug may make things worse.

 

[blackhawkxx]

Didn't want to start a new thread so I stuck it here.  I saw this today and seemed to fit in with some of the weight loss drugs talked about.

 

https://nypost.com/2024/08/14/lifestyle/personal-trainer-reveals-why-she-quit-mounjaro-after-losing-55-lbs/

[CALCXX]

Metformin has helped me. Last lab, 5.9 A1c

Now, if they would add some blue pill to it, hmmmmmm

 

 

https://www.youtube.com/watch?v=CikEbEtnBcE

 

Edited September 1, 2024 by CALCXX

[SwampNut]

https://biohackers.media/metformin-slows-aging-and-boosts-cognitive-health-in-elderly-monkeys-study-finds/

 

A recent study has added compelling evidence that metformin, a drug primarily used to treat Type 2 diabetes, may also have the ability to slow aging. The study, published in Cell, tested metformin’s effects on male monkeys and showed significant benefits in brain health, inflammation reduction, and organ rejuvenation, making metformin a promising candidate for future anti-aging therapies.