SwampNut

This is about Retatrutide, the next-generation GLP-1/GIP/Glucagon triple agonist, that I've been using for a year or so. The trials are done, it's well proven for blood sugar control as well as weight loss, and will be released soon. But it's already in use by millions of us, on the gray market and via compounding. Eli Lilly wants to stop the compounding (they can't stop the gray market). The method they are trying to use is this: The GLP-1 medications have been classified as peptides, not biologics; peptides that are FDA approved are considered drugs and allowed to be compounded if legal requirements for compounding have been met. Lilly has argued that retatrutide should instead be considered a protein; proteins and products that are “analogous” to proteins are included under the definition of “biological products” in the amended Public Health Service Act. A requirement for an agent to be classified as a biologic is that it must be greater than 40 amino acids in size. Lilly says that this particular GLP-1 has 41 amino acids,” Dr. Rumore said. Lilly describes retatrutide as having a backbone chain of 39 alpha amino acids connected via an isopeptide bond to a second backbone chain that has two or more amino acids, one of which is an alpha amino acid and one of which is not. The FDA determined that only alpha amino acids are counted toward the “greater than 40 amino acids” threshold, and further ruled that retatrutide did not qualify as “analogous to a protein” either, because it did not share the “fundamental defining property of a protein [of] being greater than 40 alpha amino acids.” https://www.pharmacypracticenews.com/Policy/Article/04-25/GLP-1-Lilly-FDA-Lawsuit/76663?omnisendContactID=6615b0d5671207aff36a8954

...You...don't understand how evaporative cooling works???

This condenser is bigger than the one it replaced, but the coils are still on the outside surface, and I've never seen a design that is not like that. It's around ten years old, it was a high (but not highest) efficiency unit for the time. Also everything is relative to location; Virginia sun and AZ sun cannot be compared. It's also not a heat pump, we have natural gas heat which is cheap and efficient. Another wild thing that I think should help, maybe more than shade, is to mist the condenser coils or provide swamp-cooled air. Obviously, if I hose down the coils, the inside temps drop a lot. Would a mist do the same? Would it offset the cost of water, filters (can't spray minerals on the coil), etc?

Has it worked for you?

This is one of the founders of the company I did my sleep/light improvements with. Their product is a skin contact sensor for critical hormones. This was a raw internal training discussion that was not intended for publication, then they realized it would be useful for many people.

Much more cost, in both buying a large enough tree, then running irrigation to it, using water for it, and cleaning up the mess it causes. There's also simply not enough room for it. The ACs are located in a walkway along the side of the house.

Yes, that thinking is what has led to many aircraft crashes, boat sinkings, etc. Definitely never take long-term reliability into account ever.

There's no shielding on any such condenser; the coils are exposed to the sun.

Bullshit or real? Seems like it should make a difference. My two units are in full sun for a few hours of the day, probably until 12-1pm or so. And if I'm going to try this, buy or build... Another possible benefit is to help prevent any amount of hot exhaust air from going back into the condenser coils.

I can't recall if I've posted about this before. These are kind of life changing, particularly in certain applications and smaller sizes. What brought this to mind is that I'd plumbed in my new compressor using the generic worm drive clamps that came with the hose barbs. They were there, at hand, and I'm lazy. It didn't take long for it to start leaking. Those standard clamps are kinda OK for large hoses, but the physics of using them on small hoses is bad. The single-ear clamps just work, every fucking time. And you don't HAVE to double them up, but for the ultimate stability, I sometimes do. They are so cheap. https://a.co/d/0ejZWNqb That tool is used both to crimp them, and break them off. And it's often super useful to clip something off flush.

An article I got today from one of the Woodworking sites. Mostly some basics on differences, kind of 101 level I think. https://www.woodshopnews.com/choosing-and-using-abrasives

So it seems. And that the vicious cycle of then being too tired to stay up until a normal circadian low is unrelated to being up too early and/or biphasic sleep problems. I'm going to add this here, good as any place I guess. Magnesium glycinate and L-theanine is a new thing I'm trying on a trusted recommendation, and the sleep tracker just told me that it has seen a 17% improvement in overall sleep quality on nights I use it. They seem to have no downside. https://a.co/d/0dUKss6e https://a.co/d/0efaBCf7

Before this, Moriah and I are getting a private backstage tour of the local Faux "News" station. Should be fun. Wish us luck.

If I have time for it, today I'd like to build a sorta quick project that will require some quick sanding. This thread inspired me to try some direct comparisons and pay more attention, my previous uses of the sample packs have been pretty casual without much thought. I have on hand: Discs: Mirka Abranet which is also called Autonet, I buy whichever is cheaper. 3M Cubitron 710W and also has some other names I forgot, this is in the video as the top choice. 3M Cubitron that is not 710W and I don't know what it is. This is not full mesh but far more holes than normal. Rectangles: Festool Granat but only in P320 I think. Powertec 4R13500 which is a mid-grade paper-type (the above are mesh). A metric fuckton of big box store junk paper with no dust holes, used for small hand jobs. That's right, a rough handjob. The rectangles go on a hand-powered block with excellent dust collection (Festool--would you pay $60 for a sanding block?). The cheap junk gets used in a variety of ways that don't really need dust collection. Here's another interesting fact; the hand sanding with integral dust collection is at least 4x better than without. Using a mesh or a paper with holes on the hand block is vastly more effective than non-vented hand sanding. Not sandpaper, but Cubitron wheels on my grinder easily double its power and longevity compared to whatever generic wheels.

Is this political if it's just known and proven fact? Can something be racist if it's true? It says his voters are fat, old, and out of shape, therefore, they would have more sleep apnea issues. The correlation between voting and CPAP usage, therefore, it can't be analyzed as to cause or just coincidence without a specific major study. You and I can just keep enjoying the unproven opinion that reversing apnea-induced cognitive disorders would reduce voting for Diaper Don. Last night I talked to one of the people I know whose life was changed by a CPAP, regarding this thread. Mike, he said to tell you that you're retarded if you don't push to do everything possible to get the study and machine (if warranted by the study). Also he pointed out that the cognitive issues caused by the apnea may be making you less able to realize you need to do this. A funny, but possible, vicious circle.

Summarize this video, particularly the ratings chart Completed 2 steps The video explains why some sandpapers cut faster and last longer than others, and its ratings chart shows 3M Cubitron mesh disks clearly outperforming most competitors on both material removal rate and durability, with several common “big box” brands clustering in the middle or bottom of the chart. Video overview The video “The Weird Physics of Sandpaper (Why You’re Working Too Hard)” from Five Duck Studio looks at how abrasive grain shape, backing, and dust extraction affect cutting efficiency and clogging. The presenter tests multiple brands on hardwood using a controlled setup (same sander, pressure, and time) to compare how much material each disc removes and how quickly performance drops off as it wears and loads with dust. What the ratings chart shows The ratings chart near the end of the video combines at least two metrics—material removal rate and time-to-failure—into an overall performance score for each abrasive. In that chart, 3M Cubitron (especially the mesh/Xtract style discs) sits at the top, reflecting both very high stock removal and good longevity, while lower-cost house brands and some “value” discs fall near the bottom due to fast loading and rapid performance decline. Key takeaways about specific abrasives The chart and commentary together indicate that Cubitron is the “clear winner” among the tested papers, particularly in coarse grits on hardwood. However, the video does not include Mirka Abranet in the tested set, so any comparison between Cubitron mesh and Abranet is based on separate user experience rather than that specific chart (for example, SwampNut’s note that Cubitron 80 grit may edge out Abranet 80 on hardwood, with parity at higher grits). Practical implications for your sanding The ratings chart implies that upgrading from cheap paper disks to a high‑performance mesh abrasive like Cubitron can dramatically increase cut rate and disk life, especially when paired with a high-flow dust extraction sander (e.g., Festool systems). It also reinforces that the sander itself matters: the same chart data will feel very different on a junk random-orbit sander versus a mid-grade or premium machine, so tool and abrasive upgrades together give the biggest real-world gain. Do you want a more grit-by-grit interpretation (e.g., what that chart suggests for 80 vs 120 vs 220 in your workflow)?

Glad I was not eating or drinking anything. I wonder if there's a stat I could pull up on this.

Oh, and that machine, or its close brother, is what my house painting pro uses for the small jobs. Not whole house, but areas, sheds, decks. He was just doing a neighbor's new garage door with it.

Those are some pretty high end products. I don't have much direct experience with outdoor finishes outside of marine spar varnish. The tint thing is mildly odd to me, because marine varnishes include totally clear UV protectants. And tints themselves don't necessarily target UV, but simply work by blocking everything slightly. Kind of like clear sunscreen for your body. It seems like there should be a specific UV additive for those products, like there is for marine finishes. But I don't know, just thinking out loud on research for you to do.

I actually wish apnea was my issue so I could solve my sleep problems instantly, as so many of my friends have. I have made some progress on the biphasic problem, and it's definitely unhealthy, with simple minerals. Unfortunately quite often, anything I ingest for health reasons, eventually becomes ineffective. My body is so good at building a new baseline and ignoring that input. My ongoing home sleep metrics, and an actual sleep study, show that CPAP won't help me.

Yeah, this seems so fucking obvious from the outside looking in, but... Apnea causes brain damage. Just sayin'.

Now I see why those kits currently show out of stock on Amazon. You got them all.

Um...there's a video above with recommendations...? I don't know what sandpaper costs any more. I switched to the mesh long ago, I know it was much more expensive than big box garbage, but haven't really thought about it again. Buying 50-packs from places like https://2sand.com/ helps with the cost compared to buying 10-packs locally. I suspect that great sandpaper on a shitty sander may not be a great investment, not sure. I went from a junk typical sander to a mid-grade Porter-Cable; huge improvement. Then the mesh discs with the upgraded holder for the PC, huge improvement. Then a high end sander (Festool with a really high end dust system (also Festool), and now I love sanding. Abranet/Cubitron mesh pair perfectly with the very high flow system in the Festool. Oh, and the AI summary says that the Cubitron is the clear winner in the video, but he didn't test Abranet. In my testing, the Cubitron 80 grit probably beat the Abranet 80 by a bit, not a lot. In higher grits I found them the same. This is all hardwood, no metal, no softwood.

LOL. I keep getting this video recommended but haven't watched. I'm not sure if you're using the word incorrectly, or using old info. Fickle=frequently changes, inconsistency. I used to be chasing that dragon, found it, and never change any more. Picky bitch, yes. A great sander and great "paper" makes such a massive difference, not one of those minor increments we often see with tool upgrades. I only use Abranet mesh, not paper, though I did recently try a sample pack of 3M Cubitron mesh.

Mostly. But in the case when I had to use three strips, not sure the single mushroom would do.