SwampNut

Summarize this video The video explains a human trial showing that statins can increase insulin resistance and sharply lower GLP‑1 levels, likely by altering gut bacteria and reducing a beneficial bile acid (UDCA), and that supplementing UDCA may reverse these metabolic effects in both mice and a small human pilot study. Key findings In 30 people starting atorvastatin vs 10 controls followed for 16 weeks, statins raised HbA1c, increased insulin levels and insulin resistance, and cut GLP‑1 levels by about 50% with a continuing downward trend. The study links these changes to a statin‑induced shift in the gut microbiome, depleting certain Clostridium species that make the secondary bile acid UDCA, which in turn appears to drive insulin resistance and lower GLP‑1. In mice, statins and microbiome transplants from statin‑treated humans reproduced insulin resistance and GLP‑1 drops, but adding back the bacteria or UDCA restored glucose metabolism and GLP‑1. A small human pilot in five long‑term statin users taking 500 mg/day UDCA improved HbA1c, reduced insulin and insulin resistance, and restored GLP‑1 levels. Author’s perspective The presenter is upset that a 2024 Cell Metabolism paper with these findings never entered mainstream or even academic medical discussion, and that most doctors he informally polled did not know statins lower GLP‑1. He argues this reflects healthcare incentive structures that favor profitable, protocol‑driven care over simple, inexpensive metabolic fixes, while stressing he is not giving medical advice and urging viewers to discuss the data with clinicians and to spread awareness.

It's amusing and sad that hospital food is nearly all garbage, nutritionally.

Huh, new thing to try.

I always use Deez nutz. But seriously, every person who's tried the balsamic-pecan things loves it. Obviously, not a traditional/real pizza.

Here in the US, we let the beef and dairy industry tell us how their products are good for us, despite both being correlated to the highest mortality and highest disease rates. We've actually made it illegal for people to show video of beef processing plants, and for companies to provide labeling showing that their product doesn't have these harmful ingredients. Follow the money. Also, we can't have socialized medicine *and* tell people to eat garbage. Until now I hadn't thought of that; where you get government health benefits, you have government advising you to eat healthy. Whoa.

LOL, also that was expected.

Agree with Dave mostly, but... The effects of nitrate-laden ultra-processed meats like salami/pepperoni and the like are pretty deep and long lasting. Small quantities have a lasting impact on your body. Here's an idea for you. Our pizza treats are made from a Jewish or mediterranean lavash, matzo, or similar low-processed bread base. There are a ton of options that are fun and tasty if you leave the Wonder Bread section of the store. Make up a sauce, red, white, whatever, with less-shitty ingredients than what Dominos is using. It's easy to do, think of the flavors and seasonings you'd like. While I try to minimize the use of oils, just some olive oil, pressed garlic, and thyme makes an amazing coating for the crust. Then we add low-processed vegan cheeses, and veggies. Tomatoes, mushrooms, onions, etc. This will sound crazy, but everyone loves it when I do it. Marinated arugula topping. Seriously. Marinate some arugula in balsamic or red wine vinegar for half an hour. It kills the bitterness and you end up with a nice green/earthy flavor, plus balsamic on a pizza is amazing. Edit to add: Don't overlook nuts as a topping. Crazy, I know. Walnuts/pecans with the balsamic are a great marriage. Pine nuts on a more traditional pie. This is "free" nutrition packed with good stuff, and a great texture adder.

Everyone thinks of magnets as attracting, but opposing magnets make a great spring. In this case they may even work without tape.

LOL, I immediately thought of "BRAWNDO! It's got electrolytes!" Adding vitamins to arsenic wouldn't make it safe, but a few of these a year isn't doing anything bad. It's the habitual users who are fucked. I once drank 11 Red Bulls in a row at a bike meetup. They were free. I think I'm fine, though the neon lights had halos and I saw a UFO on the ride home.

Very familiar with it, took me some time and lots of evidence to get a relative to kick the addiction.

That would be full retard. It's a soda with extra death.

https://nutritionfacts.org/video/which-ultra-processed-foods-are-the-worst-in-driving-the-association-with-death-and-disease TL;DR: Pizza, deli meats, burgers, candy, soda, and chicken

Something that most people don't know is that both BPC-157 and GHK are endogenous. We just might not make enough of them, so this is just boosting what your body already does. The Cu binding with GHK obviously is exogenous, and needed because we have completely fucked the copper available in our food supply. In the body, natural GHK binds to copper and both are used for angiogenesis, tissue repair, and nerve growth/repair. If you lack copper, it can't do the job.

https://blog.peptide.partners/p/ghk-cu-the-copper-peptide-thats-rewriting GHK-Cu: The Copper Peptide That's Rewriting the Rules of Regeneration How a three-amino-acid sequence discovered in human blood became the Swiss Army knife of anti-aging medicine

https://nutritionfacts.org/blog/how-low-can-ldl-cholesterol-go-on-pcsk9-inhibitors People with genetic mutations that leave them with an LDL cholesterol of 30 mg/dL live exceptionally long lives. Can we duplicate that effect with drugs? Data extrapolated from large cholesterol-lowering trials using statin drugs suggest that the incidence of cardiovascular events like heart attacks would approach zero if LDL cholesterol could be forced down below 60 mg/dL for first-time prevention and around 30 mg/dL for those trying to prevent another one. But is lower actually better? And is it even safe to have LDL cholesterol levels that low?