I've been using the 45/46's for a while now. They've handled and stuck very well for the most part. In fact, I've been very happy with all of them until recently. I had a problem with a 45 (Avon scare) a few weeks ago. I usually get about 5k miles from a rear and about twice that from a front.
I've also been riding a little harder lately and the Avons have slid on me a few times. I don't mind spinning/sliding the rear once in a while, but sliding the front end makes me uncomfortable. I think I'm going to try Pilot Powers for the next set. I'm hoping for improved grip and no handling degradation.