Statins and GLP-1 level affect

[02XXCA]

 

[SwampNut]

 

Summarize this video

 

The video explains a human trial showing that statins can increase insulin resistance and sharply lower GLP‑1 levels, likely by altering gut bacteria and reducing a beneficial bile acid (UDCA), and that supplementing UDCA may reverse these metabolic effects in both mice and a small human pilot study.

Key findings

• In 30 people starting atorvastatin vs 10 controls followed for 16 weeks, statins raised HbA1c, increased insulin levels and insulin resistance, and cut GLP‑1 levels by about 50% with a continuing downward trend.

• The study links these changes to a statin‑induced shift in the gut microbiome, depleting certain Clostridium species that make the secondary bile acid UDCA, which in turn appears to drive insulin resistance and lower GLP‑1.

• In mice, statins and microbiome transplants from statin‑treated humans reproduced insulin resistance and GLP‑1 drops, but adding back the bacteria or UDCA restored glucose metabolism and GLP‑1.

• A small human pilot in five long‑term statin users taking 500 mg/day UDCA improved HbA1c, reduced insulin and insulin resistance, and restored GLP‑1 levels.

Author’s perspective

• The presenter is upset that a 2024 Cell Metabolism paper with these findings never entered mainstream or even academic medical discussion, and that most doctors he informally polled did not know statins lower GLP‑1.

• He argues this reflects healthcare incentive structures that favor profitable, protocol‑driven care over simple, inexpensive metabolic fixes, while stressing he is not giving medical advice and urging viewers to discuss the data with clinicians and to spread awareness.

 

 

 

 

 

[DaveK]

1 hour ago, SwampNut said:

atorvastatin

I take this. 

[02XXCA]

5 hours ago, DaveK said:

I take this. 

With your weight lose and in overall better health, may be interesting to ask your doctor if reducing or eliminating statins is an option.  Maybe by eliminating statins, you could also lower your dosage of GLP-1 and stay in a healthy range.

Edited February 7 by 02XXCA

[jon haney]

Well, shit.  Now I wish I was taking a statin, so I could stop, and maybe loose a little weight.  However, my wife is taking a statin, and if she stops, might lose a little weight.  Could still be a win for me.

[02XXCA]

4 hours ago, jon haney said:

Well, shit.  Now I wish I was taking a statin, so I could stop, and maybe loose a little weight.  However, my wife is taking a statin, and if she stops, might lose a little weight.  Could still be a win for me.

Also came across a recent study that long-term statin users also lost more lean muscle than non statin users.  As you get older, so important to maintain muscle strength.

[02XXCA]

Another interesting video about Berberine in comparison to Statins with the benefits without the side effects found in statins.