Compounded Tirzepatide now illegal (Zepbound, Mounjaro)

[blackhawkxx]

Was reading this on a site targeted for people over 50.  They talked about the pros of using these drugs but here are some of the negatives they talked about. 

 

• Muscle Loss Is a Big Deal: These meds can help you shed pounds—about 19 pounds with Ozempic, 27 with Wegovy, or 45 with Mounjaro in a year. But here’s the kicker: 40% of that weight loss is muscle, including heart muscle. For us, losing muscle means a higher risk of falls, frailty, and even weaker bones. Dr. Rob says muscle is “the currency of longevity,” and I couldn’t agree more—keeping strong is key to staying active and independent.
• Side Effects Can Be Rough: Over 70% of people on these drugs deal with nausea, vomiting, or other tummy troubles. That’s why 50% quit within three months and 70% within a year. Only 23% feel fine, and many report feeling wiped out, which is the last thing we need when we’re trying to keep up with grandkids or hit the hiking trail.
• Weight Rebound: The weight loss stops after the first year, and if you quit, you often gain it back unless you’ve got a solid lifestyle plan. Dr. Rob’s perspective is about setting you up for success, not just a quick fix.

• These meds absolutely have their place, but they’re not a magic wand. Let’s talk about how we can boost GLP-1 naturally and feel amazing without the downsides.

• Link

[DaveK]

I can only medically speak for myself who lost 128 pounds on the meds and I am 17 months in.  

 

Pretty much zero side affects.  No muscle or bone density loss.  Feel amazing.  Absolutely a magic wand for me. 

[SwampNut]

13 hours ago, blackhawkxx said:

Muscle Loss Is a Big Deal: These meds can help you shed pounds—about 19 pounds with Ozempic, 27 with Wegovy, or 45 with Mounjaro in a year. But here’s the kicker: 40% of that weight loss is muscle, including heart muscle.

 

This is bullshit, so I stopped reading there and recommend you do the same.  Just a scan over the rest and it's bullshit too.  This is some clickbait hit piece probably funded by companies that profit from people eating garbage and being fat.  They are panicking.

 

4 hours ago, DaveK said:

Pretty much zero side affects. 

 

Out of the many hundreds of people I've talked to about this, you are the only one.  Although even with sides people agree it really is a magic wand.

 

[DaveK]

2 minutes ago, SwampNut said:

 

This is bullshit, so I stopped reading there and recommend you do the same.  Just a scan over the rest and it's bullshit too.  This is some clickbait hit piece probably funded by companies that profit from people eating garbage and being fat.  They are panicking.

 

 

Out of the many hundreds of people I've talked to about this, you are the only one.  Although even with sides people agree it really is a magic wand.

 

 

Same for me... almost everyone I have spoken to have either stopped the drug or reduced the dose because of side affects.  Do I have slight side affects, sure.  But absolutely nothing that has even remotely made me consider stopping.

 

Tummy ache for an hour.  Injection site soreness.  Maybe slight depression (don't really experience this anymore) 

 

No shitting problems, not massive aches, cramps, headaches... nothing. BUT.... I drink a metric shit ton of water and take 8 fiber pills a day.  I also eat clean and healthy 85% of the time.  No alcohol too.  So...  I am sure and have been told this definitely has something to do with my success.

[SwampNut]

I was interviewed for this, and am shocked at how well balanced it is.  Normally MSM just sides with big pharma.  None of the names are real in the article which I was also happy about, as I explained the problems that naming people has caused in the past.  I don't necessarily hide anything, but also not looking forward to being named in another federal complaint.

 

https://www.reuters.com/business/healthcare-pharmaceuticals/stung-by-high-prices-americans-make-their-own-weight-loss-drugs-2025-06-27/

 

Spencer, 50, is not part of any drug trial but mixes the cocktails herself, using tiny doses that she believes are safe. The total cost is about $50 monthly, as little as one-tenth of what she would expect to pay their makers for full treatment.

 

The drugs – glucagon-like peptide-1 (GLP-1) weight-loss medicines – are manufactured and shipped from China, according to the packaging. She orders them through online vendors.

 

Spencer belongs to a fast-growing group of Americans turning to what many call the "gray market" for obesity medicines, bringing cheap active ingredients from China often labeled as for research purposes, according to import data and social media postings. It's a trend that drugmakers Lilly and Novo Nordisk, which makes Wegovy, say is dangerous as well as illicit.

[tomek]

"She"? 😆 

[jon haney]

2 hours ago, DaveK said:

 

Same for me... almost everyone I have spoken to have either stopped the drug or reduced the dose because of side affects.  Do I have slight side affects, sure.  But absolutely nothing that has even remotely made me consider stopping.

 

Tummy ache for an hour.  Injection site soreness.  Maybe slight depression (don't really experience this anymore) 

 

No shitting problems, not massive aches, cramps, headaches... nothing. BUT.... I drink a metric shit ton of water and take 8 fiber pills a day.  I also eat clean and healthy 85% of the time.  No alcohol too.  So...  I am sure and have been told this definitely has something to do with my success.

So, when you said "zero side-effects", were you referring to Mike?  You must be one tough SOB to put up with that just to loose a few silly pounds.

[blackhawkxx]

2 hours ago, DaveK said:

 

Same for me... almost everyone I have spoken to have either stopped the drug or reduced the dose because of side affects.  Do I have slight side affects, sure.  But absolutely nothing that has even remotely made me consider stopping.

 

Tummy ache for an hour.  Injection site soreness.  Maybe slight depression (don't really experience this anymore) 

 

No shitting problems, not massive aches, cramps, headaches... nothing. BUT.... I drink a metric shit ton of water and take 8 fiber pills a day.  I also eat clean and healthy 85% of the time.  No alcohol too.  So...  I am sure and have been told this definitely has something to do with my success.

I would have to agree that your super clean life style has a lot to do with your success and would think that the vast majority of users wouldn't do that.  

[DaveK]

19 minutes ago, jon haney said:

So, when you said "zero side-effects", were you referring to Mike?  You must be one tough SOB to put up with that just to loose a few silly pounds.

 

LOL, Mike slept on my couch one night and that had a profound affect.  On my emotional state and my bung hole

[DaveK]

15 minutes ago, blackhawkxx said:

I would have to agree that your super clean life style has a lot to do with your success and would think that the vast majority of users wouldn't do that.  

 

I'm finding the same with people I know.  They lose it... and then slowly start to treat themselves with booze, fast food, and the "I'll start tomorrow" never comes. You can not continue to eat like a slob on the medication.  All it does is slow down your digestion and evacuation, so... you can eat yourself sick. 

 

I ordered a huge piece of chocolate cake last night after eating my grilled salmon salad for dinner.  I ate 2 table spoonful's and was done.

 

The old me was 4 Old fashioneds, wings, nachos, a full meal and a full dessert.

[blackhawkxx]

3 hours ago, SwampNut said:

This is bullshit, so I stopped reading there and recommend you do the same.  Just a scan over the rest and it's bullshit too.  This is some clickbait hit piece probably funded by companies that profit from people eating garbage and being fat.  They are panicking.

The muscle loss was the part that caught my attention and thought I would run it by you.  I know just losing weight alone makes you weaker.

I lost 65 lbs. in 2008 and have been lifting weights since junior high, the weight loss does affect muscle strength and it seems even worse as you age.  So, I just wondered about this product.  

[DaveK]

3 minutes ago, blackhawkxx said:

I know just losing weight alone makes you weaker.

 

But your dick get's bigger.

[SwampNut]

3 hours ago, blackhawkxx said:

I know just losing weight alone makes you weaker.

 

You need new sources for medical info.

 

Losing weight doesn’t inherently make you weaker, but it can if the process involves significant muscle loss or inadequate nutrition. Strength depends on muscle mass, training, and energy availability. Here’s a breakdown:

 

Calorie Deficit and Muscle Loss: Weight loss often requires a calorie deficit, which can lead to muscle breakdown if protein intake is too low or exercise isn’t prioritized. Studies show that without resistance training, up to 25% of weight lost can be muscle, reducing strength.

 

Exercise Matters: Incorporating strength training during weight loss preserves muscle and maintains or even improves strength. Research indicates that resistance training can offset muscle loss in a deficit, keeping you strong.

 

Nutrition Impact: Insufficient protein or overall calories can impair performance, making you feel weaker. Aim for 0.7–1g of protein per pound of body weight daily to support muscle retention.

 

Rapid Weight Loss: Crash diets or extreme cuts (e.g., for sports) can deplete glycogen, reduce energy, and temporarily lower strength. Gradual loss (0.5–1% body weight per week) minimizes this.

 

Body Composition: Losing fat while maintaining muscle can make you relatively stronger, as you’re moving less body weight. For example, a leaner athlete may perform better in bodyweight exercises like pull-ups.

 

Context matters—athletes cutting weight for competition might feel weaker temporarily, while someone losing fat methodically with proper training often doesn’t. If you’re losing weight and feeling weak, check your protein, training, and calorie balance. Want me to dig into any specific aspect, like a sport or diet plan?

[blackhawkxx]

3 hours ago, SwampNut said:

 

You need new sources for medical info.

 

Losing weight doesn’t inherently make you weaker, but it can if the process involves significant muscle loss or inadequate nutrition. Strength depends on muscle mass, training, and energy availability. Here’s a breakdown:

 

Calorie Deficit and Muscle Loss: Weight loss often requires a calorie deficit, which can lead to muscle breakdown if protein intake is too low or exercise isn’t prioritized. Studies show that without resistance training, up to 25% of weight lost can be muscle, reducing strength.

 

Exercise Matters: Incorporating strength training during weight loss preserves muscle and maintains or even improves strength. Research indicates that resistance training can offset muscle loss in a deficit, keeping you strong.

 

Nutrition Impact: Insufficient protein or overall calories can impair performance, making you feel weaker. Aim for 0.7–1g of protein per pound of body weight daily to support muscle retention.

 

Rapid Weight Loss: Crash diets or extreme cuts (e.g., for sports) can deplete glycogen, reduce energy, and temporarily lower strength. Gradual loss (0.5–1% body weight per week) minimizes this.

 

Body Composition: Losing fat while maintaining muscle can make you relatively stronger, as you’re moving less body weight. For example, a leaner athlete may perform better in bodyweight exercises like pull-ups.

 

Context matters—athletes cutting weight for competition might feel weaker temporarily, while someone losing fat methodically with proper training often doesn’t. If you’re losing weight and feeling weak, check your protein, training, and calorie balance. Want me to dig into any specific aspect, like a sport or diet plan?

Not reading but real life experience.  Do you think you could bench press the same amount of weight now as when you were much heavier?  

I never stopped lifting as I lost weight but my bench press went down and believe me, meat was not the thing I cut out but carbs.  There is a reason there are weight classes in weight lifting. 

  Scott mentioned he is stronger now after loosing weight but if he had worked out then like he does now, he would have been able to lift more before.

 

In no way do I think it is better to be heavier just to be stronger and even more so as you age but just stating the facts for me.  The reason I lost weight to begin with is because my hip was bothering me so much I could barely walk around a store.  After weight loss that all went away.

[SwampNut]

21 hours ago, blackhawkxx said:

Do you think you could bench press the same amount of weight now as when you were much heavier?  

 

Probably more, don't know.  The last time I lost quite a bit of weight all of my exercise measures went way up.

[SwampNut]

Reuters basically published a how-to.  They emphasize the need and benefits of self-determination and knowledge.  They cover the testing I've talked about and how to be safe.

 

 

 

 

And this is why people can't just depend on their doctor/pharmacist for advice.  There's so much lack of knowledge still.

 

https://glp1realtalk.substack.com/p/patients-threw-away-10-million-on

 

Here's a number that'll make your head spin: patients overpaid $10.2 million for GLP-1 medications in the first three months of 2025 alone.

 

I wish I was making this up.

 

A new study from DoseSpot, an e-prescribing platform, analyzed over 100,000 prescriptions for drugs like Ozempic, Mounjaro, and Zepbound. What they found was pretty depressing—92% of those prescriptions could have been filled for less money. Way less money.

 

So how did we end up here? And more importantly, why does this keep happening?

[poida]

7 hours ago, SwampNut said:

A new study from DoseSpot, an e-prescribing platform, analyzed over 100,000 prescriptions for drugs like Ozempic, Mounjaro, and Zepbound. What they found was pretty depressing—92% of those prescriptions could have been filled for less money. Way less money.

 

So how did we end up here? And more importantly, why does this keep happening?

how else will capitalism work if profits can't be maximised