The next wave of diabetes/obesity drugs are amylin agonists, not GLP-1/GIP/Glucagon

[SwampNut]

I've been using Cagrilintide for a little over a year, with good results and no side effects.  Blood sugar control is very good.  I combine it with tirzepatide, while Novo combines it with Semaglutide.  I hated that peptide though.

 

https://www.cnbc.com/amp/2026/10/02/lilly-novo-amylin-obesity-drugs.html

 

That's the early potential of a new slate of injections, pills, and combination regimens targeting the amylin pathway, which involves a hormone released in the pancreas alongside insulin that helps regulate hunger and fullness. Amylin gives Eli Lilly, Novo and several other companies another biological lever to pull in treating obesity and Type 2 diabetes, either as an independent treatment or layered on top of existing drugs. 

 

Novo's experimental amylin-based drug, cagrilintide, has shown meaningful weight loss as a standalone treatment in a late-stage trial. Combining it with semaglutide – together dubbed CagriSema – has produced even greater weight loss in clinical studies. CagriSema is expected to launch early next year, followed by standalone cagrilintide and a higher-dose version of CagriSema in 2028.

[Joel]

I read about this earlier today, it popped on my Google feed. I was going to post up on it to see how much you knew of it but I put my phone down and when I came back to it the feed had refreshed and I couldn’t find the article

 

 

[SwampNut]

I added 2.5mg of Cagrilintide on Wednesdays to complement 10-11mg of tirzepatide on Sundays.  I've noticed zero change in side effects.  Some people had warned me they had significant sides.  The CGM doesn't lie, the blood sugar control improvement was significant.

 

Eloralintide is the hot new thing though, and is documented to have fewer sides.  However the two sources I would want to get it from both just had AWFUL testing results.  Like the factories haven't figured out how to duplicate it quite perfectly yet.  Won't be long, I'm sure.

 

I just talked to someone who is in an actual clinical trial that combines Eloralintide and Mounjaro/Zepbound/tirzepatide.  Similar to what I do with Cagrilintide, except of course, cagri=Novo and tirz=Lilly so they'd never be combined.  He reports a jump in effectiveness also.

 

[SwampNut]

It looks like around $300-ish for 10 vials of Eloralintide, 10mg each, plus a few bucks for shipping and BTC exchange.  This is round 1 testing.  Usually this is good, however recently, we had a shitshow of two vendors failing once we did our own tests.

 

 

 

The process:

 

This peptide is still in China.  The manufacturer does a test.  They know we will further test, so USUALLY they don't fake anything.  Recently, a different vendor, either faked it and/or mixed vials.  That was the huge delay in re-doing the buy.

 

Then it arrives here, and random vials go to three labs.  They test, and give us the results.

 

[SwampNut]

Also this...

 

 

 

Hilariously, the gray market has already branded a Retatrutide-Eloralintide as "Loretta" before anyone even thought to make it in the primary market.  Also, "GLP-R" is code word for reta.

 

[SwampNut]

https://time.com/article/2026/10/01/next-generation-of-weight-loss-drugs-is-almost-here/

 

The Next Generation of Weight-Loss Drugs Is Almost Here

[Joel]

The article says 40% of people who start glp1 stop taking them because of side effects. I wonder how accurate that is. I didn’t notice any side effects and every person I know who started taking them is still taking them

[SwampNut]

When a person is in a controlled study, they are forced to move up in dosage on a schedule, not as their body signals it.  Doing that often leads to major side effects.  Outside of studies, people often find themselves out of money to buy them.  There's also a stat that a large percentage of people who stop them end up re-starting them later.  So while one raw number could be accurate, it's not close to the whole picture.

 

I also wonder if "stopped Mounjaro and started buying gray market" is anywhere in the stats.

 

[DaveK]

12 hours ago, Joel said:

The article says 40% of people who start glp1 stop taking them because of side effects. I wonder how accurate that is. I didn’t notice any side effects and every person I know who started taking them is still taking them

 

I have experienced the exact opposite.  Me, personally - other that maybe a psychological side affect (and I think I have beat that now) almost every person I know has had a side effect.  Some so bad that they  had to come off the drug and go on an alternative.   

[SwampNut]

Dave is a 1%er, lol.  Nearly everyone at his dose has major side effects.  Crazy.

 

[DaveK]

25 minutes ago, SwampNut said:

Dave is a 1%er, lol.  Nearly everyone at his dose has major side effects.  Crazy.

 

 

Truth - most of what I hear is "cramps that are debilitating" and major gastro issues. 

 

I beat the psych issue by changing 2 things.  I stepped the dose down a touch...and second, stopped going 10 days between doses and went back to 7.  A combo of the 2....and mentally, I have been good.  

[Joel]

2 hours ago, DaveK said:

 

Truth - most of what I hear is "cramps that are debilitating" and major gastro issues. 

 

I beat the psych issue by changing 2 things.  I stepped the dose down a touch...and second, stopped going 10 days between doses and went back to 7.  A combo of the 2....and mentally, I have been good.  

Interesting and good to know there are potential workarounds should issues come up

[SwampNut]

There are many solutions to the various challenges.  For me, magnesium and a few other things have stopped the constipation issues.

 

Also early on, lots of people react very poorly to fatty meats, fried food, and dairy.  Watch those for a while.  I removed them all from my diet outside of going wild on a trip with wings.

 

[DaveK]

14 minutes ago, Joel said:

Interesting and good to know there are potential workarounds should issues come up

 

100% - there are adjustments and work arounds.  I think people give up too quickly.  

[SwampNut]

2 minutes ago, DaveK said:

I think people give up too quickly.  

 

That's all of life, right?  Unfortunately part of the problem is that doctors have such low knowledge, still, on how to help manage GLP-1 usage.  Many even are directly misinformed and give patients false info.

 

[DaveK]

True...but not all. And most of who I take direction from is my family.